The effect of pomegranate on depression, anxiety, and food intake in ovariectomized rats. Results among ovariectomized rats, the acupuncturetreated rats had significantly lower body weights and crosslinked ntelopeptide of type 1 collagen levels in the. In a third cohort, the effect of exogenous estrogen and a selective estrogen. Psychoimmunological effects of dioscorea in ovariectomized rats. It is well established that rats develop cancellous bone osteopenia in the appendicular and axial skeleton after ovariectomy 3, 4. Twentyfour animals weighing 160180 g were purchased for the study n8 group harlan laboratories, madison, wi. Urine samples were obtained as spot samples by placing the rats in a metabolic cage for 30 to 60 min and waiting for them to urinate. Hepatoprotective effects of morinda citrifolia leaf extract on ovariectomized rats fed with thermoxidized palm oil diet.
In the present study, an ovariectomized female rat model was used to. In addition, ovariectomized rats exhibited a greater rate of longitudinal bone growth relative to shamoperated control rats. Alternatively, you can download the file locally and open with any standalone pdf reader. This study was aim to evaluate the antiosteoporosis effects of rabbiteye blueberry in ovariectomized rats. After eight weeks of treatment of fll or water, the lumbar spine was scanned by peripheral quantitative computed tomography. In assessing the relationship between calcium supplementation and maintaining bone mass or reducing the risk of fracture, the effectiveness of calcium supplementation has never been decisive. Ovariectomized rats were treated with a single intravenous iv dose of. Walsh department of physiological sciences, college of veterinary medicine, box j. Interaction of sex hormones and the reninangiotensin system in ovariectomized rats subjected to ischemiareperfusion induction. Pdf effect of diosgenin on the circulating microrna profile.
The present study investigates the antiosteoporotic activity of fll aqueous extract in the model of postmenopausal bone loss in aged ovariectomized ovx female rats. Evaluation of estrogenlike activity of nigella sativa in. Preserved bone mass in ovariectomized rats treated with. Pdf hepatoprotective effects of morinda citrifolia leaf. This article is from bmc complementary and alternative medicine, volume 14. We aimed to assess the effect of ovariectomy on cartilage turnover and degradation, to evaluate whether ovariectomized ovx rats could form an experimental model of postmenopausal osteoarthritis. Female rats with lesions of the ventromedial hypothalamus vmh were ovariectomized during the static obese stage efter body weight levels had stabilized. Soyinduced fecal metabolome changes in ovariectomized and. The aim of the present study was to examine the effects of isoflavones obtained from cordyceps sinensis csif on development of estrogen deficiencyinduced osteoporosis in ovariectomized rats. Osteoporosis poses a significant public health issue. An analgesic effect of calcitonin has been observed and reported in clinical situations. Four groups of 78monthold rats were treated sc daily for d with pthrp 4 or 107111.
Rats were fed the commercial solid diet during the 7d recovery period. Extracellular regulated kinase 5 mediates osteoporosis. Research article open access ovariectomized rats as a. What effect did the administration of saline injections have on the control rat. Aug 30, 2009 estrogen therapy is widely used nowadays in women to treat many postmenopausal symptoms but it may have some undesirable effects due to multiple organs affection. Resveratrol prevents osteoporosis in ovariectomized rats by. Bazedoxifene, a selective estrogen receptor modulator. Effects of chronic estradiol treatment on the thyroid gland.
How does the fact that the rats are ovariectomized explain. Download fulltext pdf download fulltext pdf highfat diet intake induces depressivelike behavior in ovariectomized rats article pdf available in scientific reports 91 december 2019 with. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs. Taurine prevents hypercholesterolemia in ovariectomized. Osteoprotective effects of fructus ligustri lucidi aqueous. With no effect on the blood pressure, treatment with 0. After the rats were treated orally with csif, serum alkaline phosphatase alp, tartarate resistant acid. Vmhnlesioned rats than that produced by lesions alone. Highsaturatedfat, highsucrose diet aggravates bone loss in. Recently, a novel phytoestrogen, 3r1,7diphenyl4e,6e4,6heptadien3ol or compound 049, has been isolated and no study thus far has investigated the role of c. Bone loss prevention in ovariectomized rats using stable.
Treatment with metformin diminished approximately 50% of the mass gain observed in ovariectomized animals and reduced both the serum and hepatic triglyceride levels. Rabbiteye blueberry prevents osteoporosis in ovariectomized rats. Resistance training and glycogen content in ovariectomized rats article pdf available in international journal of sports medicine 337. The aim of this study was to evaluate the osteoprotective effect of aqueous rhizoma dioscoreae extract rde on the alveolar bone of rats with ovariectomyinduced bone loss. The combination of high calcium milk with citrus maxima peels. Thirty rats were randomly divided into three groups of ten rats each as follows. The effects of estrogen administration upon epidermal. Ovariectomy yielded higher food intake and weight gainin. Spraguedawley ovariectomized ovx rats were utilized for this study to eliminate endogenous hormone production. Proteomics in plasma of ovariectomized rats and those exposed. Pdf effect of acupuncture at acupoint of shenshu bl 23.
The effects of estrogens on food intake and body weight following. Female wistar rats were divided into the following groups. During the feeding study, rats were allowed free access to doubledistilled water and their corresponding diets. Effect of body weight on osteopenia in ovariectomized rats. Jun 07, 2012 when rats and mice are used in estrogen research they are commonly ovariectomized in order to ablate the rapidly cycling hormone production, replacing the 17. Ovariectomized rat an overview sciencedirect topics. The ovariectomized ovx rats were treated with vehicle ovx, estradiol valerate ev, or rde. Why were ovariectomized rats used in this experiment. Jul 11, 2019 escitalopram ameliorates cognitive impairment in dgalactoseinjected ovariectomized rats. Hello my name is jolie smudin and i would like to request a copy of the video. Here, we hypothesized that serotonergic neurons in the central nervous system cns, which have anorectic action and play a role in regulating circadian rhythm, mediate the light. Bone loss prevention in ovariectomized rats using stable amorphous calcium carbonate abstract fulltext html download as pdf size. Ethanolic extract of secang heartwood caesalpinia sappan l.
Since collagen is the most abundant protein in the bone matrix, and since hydroxyproline is an imino acid nearly exclusive to collagen, a monitoring of the metabolism of hydroxyproline in ovariectomized and estrogen treated. The combination of high calcium milk with citrus maxima. The phytoestrogen genistein produces anxiolyticlike effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. Metformin ameliorates body mass gain and early metabolic. Effect of oligofructose or dietary calcium on repeated calcium and phosphorus balances, bone mineralization and trabecular structure in ovariectomized rats volume 88 issue 4 katharina e. Estrogen therapy is widely used nowadays in women to treat many postmenopausal symptoms but it may have some undesirable effects due to multiple organs affection. View ovariectomized rats research papers on academia. Freshwater crayfish rely on amorphous calcium carbonate acc, an instable polymorph of calcium carbonate, as the main mineral in the exoskeleton and in the temporary storage organ, the gastrolith. Effects of chronic estradiol treatment on the thyroid. Pdf the effects of stretching on muscle morphometry of. Pellis, the brain as the engine of sex differences in the organization of movement in rats, in archives of sexual behavior, volume 37, number 1, doi. An ovariectomized rat ovx is a female rat whose ovaries have been removed. Study of the effect of ovariectomy in ovx rats for these studies, two cohorts of 20 virgin female spraguedawley rats were used. In a third cohort, the effect of exogenous estrogen and a.
After treatments, the bone mineral density bmd and. One group of 8 ovariectomized rats received only the vehicle 0. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Pomegranate extract improves menopausal syndrome in. The present study aimed to investigate the effects of extracellular signalregulated kinase erk 5 erk5 on postmenopausal osteoporosis by regulating the biological behaviors of osteoblasts. They were used since they no longer produce estrogen and this experiement tested estrogen therapy or calcitonin therapy. After eight weeks of treatment of fll or water, the lumbar spine was scanned by peripheral quantitative computed. Attention has been paid recently to the pineal gland as a receptor of light. Patterns of hydroxyproline excretion in ovariectomized and. Effect of oligofructose or dietary calcium on repeated. It has been forecasted that the rabbiteye blueberry could inhibit osteoporosis. Rhizoma dioscoreae extract protects against alveolar bone.
Calcitonin is used as a treatment to reduce the blood calcium concentration in hypercalcemia and to improve bone mass in osteoporosis. Abstractin previous studies, we found that the consumption of legumes decreased bone turnover in. Postmenopausal osteoporosis is a common condition characterized by the increase and activation of osteoclasts. There is, however, lack of consensus regarding how the hormone should be administered to obtain physiological serum concentrations. Our previous study demonstrated that chronic estrogen replacement in ovariectomized rats reduces food intake and augments cfos expression in the suprachiasmatic nucleus scn, specifically during the light phase.
Ahn kh, yi kw, park ht, shin jh, hur jy, kim yt, kim sh, lee kw, kim sh, bae cs, kim t. Nutrients free fulltext fluoxetine mimics the anorectic. Soyinduced fecal metabolome changes in ovariectomized and intact female rats. Ovariectomaized ovx rats exhibit the same hormonal changes as observed in humans with osteoporosis and are an animal model of postmenopousal. Description of a new method of ovariectomy in female rats. If this is done to a girl who has not yet reached puberty, it prevents the development of secondary sex characters. If nuclear binding sites for estrogens exist in bone cells, then the origin of estrogendeficiencyinduced osteopenia may be at the level of bone matrix protein synthesis. Resistance training and glycogen content in ovariectomized. Fructus ligustri lucidi fll is a commonly used herb for treating bone disorders in chinese medicine. Effect of body weight on osteopenia in ovariectomized rats t. Pdf the present study aimed to assess the changes in circulating microrna mirna expression profiles associated with the potential osteoprotective. Taurine prevents hypercholesterolemia in ovariectomized rats. Nigella sativa reverses osteoporosis in ovariectomized rats.
How does the fact that the rats are ovariectomized explain their baseline t scores. Wed like to understand how you use our websites in order to improve them. Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison. Effects of ovariectomy and estradiol injections on food intake and. Pdf ovariectomized rats as a model of postmenopausal.
If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. If both ovaries are removed from an adult woman, reproduction is not possible and the female sex. Ovariectomy definition of ovariectomy by medical dictionary. For bone density studies, ovariectomized rats 8 per group were treated daily with raloxifene 100. Pdf we aimed to assess the effect of ovariectomy on cartilage turnover and degradation, to evaluate whether. Osteoporosis is a disease characterized by loss of bone mass and. The effects of cordyceps sinensis phytoestrogen on. Evidence at histological and ultrastructural level. If you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs. Download this pdf file the pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Spraguedawley sd rats were ovariectomized to develop an osteoporosis model. Ovx rats provide a useful experimental model for the evaluation of the chondroprotective effects of.
As early as 1985, ovariectomized ovx rats were used. Isoflavones are naturally occurring plant chemicals belonging to the phytoestrogen class. The hypox rats also had high bmr after injections making the rat hyperthyroid. Pdf effect of diosgenin on the circulating microrna. It would do wonders in helping with my senior thesis. Female wistar rats underwent either ovariectomy or sham operation sham. After two weeks from the operation, all rats received the following treatments by lavage administration from 8. The 4 groups were lfssham, hfssham, lfsovx, and hfsovx. Since their is no estrogen produced to offset the osteoporosis. So, the aim of this study was to determine the effects of chronic estradiol treatment on the structure and function of the thyroid gland in ovarictomized rats as a model simulating menopause. However, there are some major differences between rat and human bone physiology and it remains to be clarified whether the ovariectomized rat can serve as a model for postmenopausal osteoporosis. Iii, ovariectomized rats receiving a low, physiological dose of estrogen. Pdf nondigestible oligosaccharides increase calcium.
The purpose of the current study was to evaluate estrogenic activity of nigella sativa using ovariectomized ovx rats. Apr 26, 2011 the most common animals that are used for experimental studies are rodents, mainly rats and mice. Skeletal alterations in ovariectomized rats springerlink. The rats wont produce any estrogen since the ovaries are removed. Effect of singled and mixed pomegranate on postmenopausal symptoms in overiectomized rats. Ovariectomized rats as a model of postmenopausal osteoarthritis. However, no studies have directly compared the effects of identical doses of genistein and 17. Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. The pineal gland has been considered an organ which relates to sexual maturity since gutzeit 1 had detected a pineal tumor in a case of precocious puberty.
How well did the results compare with your prediction. We report an efficient method of ovariectomy and compared this method with the two other operative methods of ovariectomy i. Why were ovariectomized rats used in this experiment how does. The aim of the study was to evaluate the effects of stretching on muscle morphometry in ovariectomized rats. Pomegranate seed hydroalcoholic extract improves memory. Chlorogenic acid prevents osteoporosis by shp2pi3kakt. The effect of ovariectomy on cartilage was studied using two cohorts of female spraguedawley rats, aged 5 and 7 months. Improvements of insulin resistance in ovariectomized rats. Nov 29, 2010 fructus ligustri lucidi fll is a commonly used herb for treating bone disorders in chinese medicine. Why were ovariectomized rats used in this experiment how. The dosage was adjusted with the increase in body weight.
Escitalopram ameliorates cognitive impairment in dgalactoseinjected ovariectomized rats. When rats and mice are used in estrogen research they are commonly ovariectomized in order to ablate the rapidly cycling hormone production, replacing the 17. Highsaturatedfat, highsucrose diet aggravates bone loss. Psychoimmunological effects of dioscorea in ovariectomized. Proteomics in plasma of ovariectomized rats and those. Both small animals and large animals are used depending on which aspects of the osteoporotic condition are. Ovariectomized definition and meaning collins english. This article is from nutrition research and practice, volume 7. An immunohistochemical study of the antinociceptive effect.
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