Ifosfamidebased combination chemotherapy in advanced soft. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Ifex ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Johns wort may decrease ixabepilone plasma concentrations unpredictably and should be avoided safety information. Avoid runoff into storm sewers, ditches, and waterways. Dosage and duration of treatment andor treatment intervals depend on the. Assay preparation select an accurately counted number of containers of ifosfamide for injection, the combined contents of which are equivalent to about 6 g of ifosfamide.
Potential adverse reactions from prescribed doses and overdoses are described in the package insert. Ifosfamide comes as powder to be mixed with liquid to be injected over at least 30 minutes intravenously into a vein by a doctor or nurse in a medical facility. Ifosfamide is passed into the breast milk and may cause neutropenia, thrombocytopenia, low haemoglobin concentrations and diarrhea in children. Eastern cooperative oncology group phase ii trial of ifosfamide in.
If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016. Aim may be given with the goal of cure, and while not always curative, it may still relieve symptoms and prolong life. Ifosfamide can be toxic to the bladder, and may cause hemorrhagic cystitis, a condition associated with bladder irritation and blood in the urine. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian cancer. Ifosfamide, carboplatin, and cisplatin can cause renal complications, including acute tubular dysfunction, although carboplatin is less nephrotoxic than cisplatin. Pdf ewings sarcoma and primitive neuroectodermal tumor of bone are closely. Ifosfamide can also cause hypophosphatemic rickets. Ifosfamide definition of ifosfamide by medical dictionary. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight ww at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. Ifosfamide powder for solution for injection drug summary. Ifosfamide, like cyclophosphamide, is an oxazophosphorine alkylating agent. Your doctor knows this can happen and, if necessary, he or she will give you a medicine called mesna which will protect your bladder. Mesnex tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide.
Used as an antineoplastic agent in treatment of leukemia, lymphoma, and cancers of the lung, ovary, testes, and other organs. Rituixmab binds to the surface of the cancer cell, while ifosfamide. The length of treatment depends on how well your body responds to treatment with. The dosage is based on your medical condition, body size, and response to treatment. Risk factors for ifosfamide nephrotoxicity include. Neurotoxicity related to the use of ifosfamide is a wellknown complication. Ifosfamide for injection ifosfamide for injection, usp singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide ifx is an agent as yet unstudied in advanced.
The most efficient way to insert pdf into word editable, multipage if you want to insert a multipage pdf into word and edit on the inserted pdf as well, the most efficient way is to do a pdf to word conversion. Some health conditions may make you more susceptible to the sideeffects of the drug. Guidelines for the administration of mesna with ifosfamide. Ifosfamide can pass into breast milk and may harm a nursing baby. Ifosfamide exhibits dosedependent pharmacokinetics in humans. Accidental release measures contain spill and collect, as appropriate. Mesnex may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below. Store in accordance with information listed on the product insert. Ifosfamide side effects, dosage, interactions drugs. Pdf successful treatment of ifosfamide neurotoxicity. Ifosfamide interferes with oogenesis and spermatogenesis. Mesna can either be given to you as a short injection, or mixed into the drip solution with your ifosfamide, or as tablets. Two of s the rct 10, 12 reported that the addition of ifosfamide to an anthracycline regimen either doxorubicin, or doxorubicin and dtic significantly. Mesna can be given as an intravenous iv injection or as a tablet.
Animal studies indicate that the drug is capable of causing gene mutations and. The acute tubular dysfunction can be manifested by increased excretion of potassium, phosphorus, and magnesium. Click on the rituximab package insert below for reported side effects and. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2. Ifosfamide is a synthetic structural isomer of cyclophosphamide that has been approved for concurrent use with other drugs usually cisplatin, etoposide, or vinblastine in the treatment of metastatic germcell testicular cancer and some especially pediatric sarcomas. The remaining seven phase studies ii, 29 34 used ifosfamide in combinations that did not include an anthracycline. Mesnex mesna is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. Ifex ifosfamide for injection singledose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Confusion and coma have been associated with the use of ifosfamide, and antiepileptic drugs may be required. Germ cell tumors with somatic transformation into pnet have in certain cases been successfully treated with chemotherapy that includes cycles of. Mesnex injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage ww at the time of ifosfamide administration. The vial and vial stopper are not made with natural rubber latex. A high fluid intake will help prevent bladder irritation. Please refer to full prescribing information, including boxed warning.
Due to its urotoxic effect, ifex should not be administered without the use of a uroprotective agent such as mesna. Mesnex is indicated as a prophylactic agent in reducing. Ifosfamide solution for injection drug information, side. Encourage your child to drink twice the normal amount of fluids for 24 hours after ifosfamide is given. Contain spills with an inert absorbent material such as soil, sand or oil dry. Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The most common adverse reactions in chemotherapyinduced nausea and vomiting in. Clinical pharmacology of ifosfamide and metabolites. Dissolve the contents of each container in water and combine all of the solutions in a ml volumetric flask.
Ifosfamide ifo, sold under the brand name ifex among others, is a chemotherapy medication used to treat a number of types of cancer. Ixempra ixabepilone dosing and administration guide. Ifosfamide is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms. Ifosfamide is given intravenously by iv usually once a day for five days every three weeks. Ifosfamide can damage the lining of your bladder, causing bleeding into your urine. The total daily dose of mesnex is 100% of the ifosfamide dose. This medication is given by injection into a vein by a health care professional.
Ifosfamide medical definition merriamwebster medical. Ifex is an alkylating drug indicated for use in combination with certain other. You may be able to overcome this with stronger flavored herbs such as basil, sage, or thyme. We do not have evidence of the benefit of adding etoposide and ifosfamide in the. Find patient medical information for ifosfamidemesna intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ifosfamide fda prescribing information, side effects and. Following activation in the liver, ifosfamide interferes with dna through formation of phosphotriesters and dnadna crosslinks, thereby inhibiting protein synthesis and dna synthesis. Dailymed ifex ifosfamide injection, powder, for solution. Before using ifosfamide, inform your doctor about your current list of medications, over the counter products e. Mesna equivalent of 40% total daily ifosfamide dose given as iv bolus postifosfamide mesna equivalent of 40% total daily ifosfamide dose given orally 2 and 6 hours after the end of the ifosfamide infusion. Pdf addition of ifosfamide and etoposide to standard. Sections or subsections omitted from the full prescribing information are. Aim is given to shrink tumors and alleviate symptoms of sarcoma. Ifosfamide is contraindicated for breastfeeding see section 4.
Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. Ifosfamide is 32chloroethyl22chloroethylaminotetrahydro2h1,3,2oxazaphosphorine 2oxide. Tap along the timeline to move to different parts of the audio file. This typically regresses after completing treatment. The molecular formula is c 7 h 15 cl 2 n 2 o 2 p and its molecular weight is 261. Ifosfamide is a parenterally administered alkylating agent similar to cyclophosphamide that is used in the treatment of several forms of cancer including lymphomas, sarcoma and advanced forms of solid organ cancer such as breast, testicular, ovarian, gastric and lung cancer. Rinse each container with water, and add the rinsings to the volumetric flask. Ifosfamide therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute.
Voorma, ingevolge het besluit van het college voor promoties. While the use of methylene blue is a known antidote, symptomatic treatment of the central nervous system cns effects. A new drug combination, ifosfamide and etoposide, was highly effective in patients with. Ifex ifosfamide dose, indications, adverse effects. For more information, go to edit pdf content in word. Ifex ifosfamide for injection, usp 1 gm single dose vial. The active ingredient, mesna, is a synthetic sulfhydryl compound designated as sodium2mercaptoethane sulfonate with a molecular formula of c 2 h 5 nao 3 s 2 and a molecular weight of 164. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. While, a good pdf to word converter will make things quite easy and simple, allowing users to retain the same layout, format and image quality in the word output as original pdf, to. Ifosfamide has been included in various salvage regimens after relapse following bep therapy. Injections are prepared for parenteral use by adding sterile water for injection, usp, or. Store intact vials at room temp or under refrigeration.
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